Sensitive Period for a Multimodal Response in Human Visual Motion Area MT/MST

TitleSensitive Period for a Multimodal Response in Human Visual Motion Area MT/MST
Publication TypeJournal Article
Year of Publication2010
AuthorsBedny, M., Konkle T., Pelphrey K., Saxe R., & Pascual-Leone A.
JournalCurrent Biology
Volume20
Issue21
Pagination1900 - 1906
Date Published11/2010
ISSN09609822
Abstract

The middle temporal complex (MT/MST) is a brain region specialized for the perception of motion in the visual modality [1–4]. However, this specialization is modified by visual experience: following longstanding blindness, MT/MST responds to sound [5]. Recent evidence also suggests that the auditory response of MT/MST is selective for motion [6,7]. The developmental timecourse of this plasticity is not known. To test for a sensitive period in MT/MST development, we compared MT/MST function in congenitally blind, late blind and sighted adults using fMRI. MT/MST responded to sound in congenitally blind adults, but not in late blind or sighted adults, and not in an individual who lost his vision between ages of 2 and 3 years. All blind adults had reduced functional connectivity between MT/MST and other visual regions. Functional connectivity was increased between MT/MST and lateral prefrontal areas in congenitally blind relative to sighted and late blind adults. These data suggest that early blindness affects the function of feedback projections from prefrontal cortex to MT/MST. We conclude that there is a sensitive period for visual specialization in MT/MST. During typical development, early visual experience either maintains or creates a vision-dominated response. Once established, this response profile is not altered by longstanding blindness.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0960982210011620
DOI10.1016/j.cub.2010.09.044
Short TitleCurrent Biology

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